The Microbiome in Epilepsy

Epilepsy can be viewed as a constellation of disorders all of which share the common feature of unprovoked seizures. Although inherited genetic factors are known to play a role in epilepsy, in most cases, the underlying cause of an individuals’ epilepsy remains unknown.

Our understanding of the role of the microbiome in the development and treatment of epilepsy is very much in its infancy. However there are some intriguing findings suggesting a relevant and important role. For example in a variety of central nervous system diseases, there is growing support for an aetiological link between the gut microbiome and the brain. The exact pathways of communication are slowly being unraveled with a key role for the immune system, especially T cell function.

FutureNeuro can enable access to a large, research-engaged population of people with epilepsy, some of whom are already engaged in microbiome-related studies. Insight can provide support in implementing existing, or developing novel approaches to microbiome analysis. Collectively, NeuroInsight would make an excellent environment for a Fellowship focused on the microbiome in epilepsy, as well as other neurological conditions.

To explore this project further, please reach out to Gianpiero Cavalleri – gcavalleri@rcsi.ie or email NeuroInsight – neuroinsight@rcsi.ie